For those not familiar with all that has changed since then, here's a list of the big differences between Third Edition and our version of the World of Darkness.
Gehenna
Gehenna has not happened. We still may be in the Final Nights, but the coming of Caine is not on the horizon just yet.
The Week of Nightmares
The Week of Nightmares never occurred. The Ravnos are still a major and thriving clan, and Ravenna slumbers somewhere in the world still.
Clan Malkavian
Non-Sabbat Malkavians still have Dominate as their in-clan disciplines, and do not have access to Dementation. There is no Malkavian Madness Network, or Malk Time and related abilities.
Clan Gangrel
The Gangrel never left the Camarilla, and there was no fiasco surrounding their Inner Council members. The Gangrel are just as much outsiders as ever, however.
Clan Assamite
The Assamites still labor under their curse. Their reputation as honorable assassins remains untarnished. No Assamites have joined the Camarilla, enjoying their status as independents.
Tremere Antitribu
House Goratrix has not been destroyed. The small brood of Tremere Antitribu still exists within the Sabbat.
The Anarch Free States
The Anarch Free States still control the West Coast of the United States, and continue to try and spread their revolutionary message across the rest of the continent. The Cathayans have stayed in the East, where they belong.
The Sabbat
The Sabbat have retained their control of New York and Montreal, making the East Coast an occassional battleground for supremacy in the United States. Their hold on Mexico is as absolute as ever.
Salubri Antitribu
This clan does not exist in 2nd Edition.
Harbingers of the Skulls
This clan does not exist in 2nd Edition.